https://www.nicoleethen.com/home daily 1.0 2025-04-05 https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/abb1dca4-f01a-4a2d-89df-7b8772097051/tavr_coverimage.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587860873665-MDXGDM0IVAQ8BMGD41NK/AnatomicalHeart_NJEv3_150ppi.jpg Home https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/af86a94b-6e03-4ff5-a4a0-cee0a7f671ae/HIV-viral-infection_NE_2018_watermarked.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587855497538-4O1JPLV7858B0746D9BF/NephroticAnim_150.jpg Home https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587833870009-1JEPBQ12GZPV9GV0FQ94/Chromosome_screenshotblue-150p.jpg Home 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Sketchbook Gallery https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587836779705-JFCYMJYRVOW2DCEH055N/4D1137B3-34DB-4156-B442-545C991C6B4E.jpg Sketchbook Gallery https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587836783713-Y0J6Q28A86ZZU5C5R248/7BF96358-C04C-4451-9732-DCE47AA2E9F5.jpg Sketchbook Gallery https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587836771534-4F717VOOUD7M5IEAFFAW/74C7FD67-159F-4AA3-8C65-0445BCBC2DFD.jpg Sketchbook Gallery https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587836779166-TRA0C4QD41WV86FGVAAN/0C6738F9-1232-4C22-8690-719996378245.jpg Sketchbook Gallery https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587836759188-VJO91EN0EEPSXD1YIAK5/EB7BBBD3-20C8-4209-BBF8-4B92756C2CA5.jpg Sketchbook Gallery https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587836785955-VC1N74RWZIQ7H4IOR0Y7/BB15B13B-F15F-4F16-93CC-417DB44649F5.jpg Sketchbook Gallery https://www.nicoleethen.com/toxoplasmosis-animation daily 0.75 2020-04-26 https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1549693080297-2YB246ZH6H38XRN7KTGT/Scene2.PNG Toxoplasmosis Animation https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1549691232331-543ITTBPYX6HI3RIR9NF/progress-AE.PNG Toxoplasmosis Animation https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1549690145063-L8SZZWFHNOLF6YP6IJUE/Screen%2BShot%2B2018-10-27%2Bat%2B12.44.46%2BPM.jpg Toxoplasmosis Animation https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1549690421404-ZCDOSAQL1LXSYI18G7XD/progress_scene2.png Toxoplasmosis Animation https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1549694513927-VYHNFFNJLH1VNUB7GSVN/CatIntestines_FinalAnimation.jpg Toxoplasmosis Animation https://www.nicoleethen.com/grad-research daily 0.75 2020-02-14 https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581657760606-6KZGJL2B4PCPTYQLZ5ZJ/Screen+Shot+2020-02-12+at+9.23.40+PM.png Graduate Research https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581569245616-YY2KS83YCR45LU8OHEI7/Chromosome_screenshot-150p.jpg Graduate Research https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581655755339-KV9MM9AL0F4UE9RYBAHD/Storyboardv4_page1.jpg Graduate Research The first page of the approved storyboard, including a motion graphics title scene. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581658254653-5CFC2L4ADZDD885KVDTP/DNMT3_labeled.jpg Graduate Research A screenshot from VMD of the DNA methyltransferase 3 (DNMT3) with important structural features noted. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581657865565-WEWPFR7EOHRLA60UTQAN/Screen+Shot+2020-02-12+at+9.23.16+PM.png Graduate Research A style shot from the 2D version of the animation that was tested on participants. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581655705359-ZW3T02TWFXGC06UQMTO7/SB1-pg1.jpg Graduate Research An early version of the first page of the storyboard. The first frame was the only part that remained after multiple storyboard revisions. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581657921279-B03124EO2S66B7GB47FQ/TitleSeq_Particles+%280-00-03-02%29.jpg Graduate Research I had to exercise my graphic design skills in order to make this lengthy title more approachable. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581658039282-YWO4CN21KTSCXRLYI2ZP/SQI-first.jpg Graduate Research A sketch from a frame in my storyboard…. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581658089614-6MU951NVD9QUNXG5UYU3/glove-test-render.jpg Graduate Research ….to a test render of the models and materials and preliminary liquid simulation. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581656588227-DK9BXY8OU6F7MEIBQHXO/GLOVE-highpoly.PNG Graduate Research A screenshot from ZBrush of the gloved hand that was modeled and later animated. High poly meshes were projected onto a low poly object in the final animation. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581655672612-UB4ZUNX9VE9JN42DP7N7/Testing+Styles+Comparison Graduate Research I was interested in whether 2D or 3D visual styles would influence learning or interest as well as the addition of text onscreen. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581656964884-D913RTPWL27CAZB2207O/scene7_progress20190224.PNG Graduate Research A screenshot of the workspace in 3ds Max showing the helper objects used to animate these elements such as splines, dummies, point helpers, and bones. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581656399101-V6X09ONYTRLSEQ6FOZV3/chromatin_building.PNG Graduate Research A screenshot of the workspace in 3ds Max while creating the chromatin fiber and compacting nucleosomes. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581657742199-127436RLP46JTDCYXJIJ/Screen+Shot+2020-02-12+at+9.23.50+PM.png Graduate Research Modeling and simplification of the histone octamer https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581658271403-BW5PCQGHFYMC7WXY5H72/PCAF_domains.jpg Graduate Research A screenshot from VMD of the histone acetyltransferase PCAF with important structural features noted. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581656920588-JQ4ERGRNONTQU9NHKQD0/Chromosome.PNG Graduate Research A screenshot of the workspace in 3ds Max while exploring different ways to compact the chromatin into the chromosome. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587846427832-WSFNJUPZ48GVH9YIMJEN/2d_chromatin-fiber.jpg Graduate Research https://www.nicoleethen.com/stony-coral-reproduction daily 0.75 2020-04-26 https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587868116039-VF8B1PKZGIEY9NUQVRUL/zbrush-screenshot-corals.jpg Stony Coral Reproduction Screenshot from ZBrush where all models were sculpted and painted. Models were then exported to Keyshot for rendering, composited in Adobe Photoshop, and labels completed in Adobe Illustrator. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581575572665-SO6RRWOXDE73SVZSFSWB/Ethen_N_StonyCoralReproduction.jpg Stony Coral Reproduction https://www.nicoleethen.com/about daily 0.75 2025-04-27 https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587832067289-3Y2GH5OZ1T707LG8LI3F/IMG_2125.jpg About https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587838057205-U7B1RNB2OXYTKCIOH069/AMI_Member_RGB_2color.png About - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.nicoleethen.com/animation daily 0.75 2025-04-05 https://www.nicoleethen.com/contact daily 0.75 2020-04-25 https://www.nicoleethen.com/otoscope-animation daily 0.75 2020-04-26 https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587850445862-W25LB0F0KRYBPBJ0MHV1/otoscope_process_lighting-mtls_2019.jpg Otoscope Animation Once the model was completed, I created materials and set up the lighting. The completed models replaced the primitive models that had been preliminarily animated. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587852078660-2LHGNC1MCA44KQT9TMVG/otoscope_process_primitive-model.jpg Otoscope Animation I started by modeling a ‘primitive’ otoscope in order to establish the correct dimensions and to begin working with Edith to develop a preliminary animation. https://www.nicoleethen.com/3d-modeling daily 0.75 2025-04-05 https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/b74fbef4-6303-4372-b6ac-80d88aafd540/Figure_4E_v4_watermarked.png 3D Modeling - Make it stand out A 2D/3D blend figure for publication showing the effect of pausing of RNA Pol II based on presence or absence of the NELF protein complex. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/51283432-5c92-44a9-9d0a-fe64c15c38c0/h3_histone-code_NE_2020_watermarked.png 3D Modeling - Make it stand out An image for a presentation slide, this blend of 2D and 3D was intended to showcase the differing effects on transcription of adding a methyl or acetyl group to histone H3. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/f5ee11c4-0772-46fe-87ad-2cc689168956/Chromosome-DNA-RNA-Protein_NE2019_watermarked.png 3D Modeling - Make it stand out Image showing progression from chromosome -> DNA -> mRNA -> protein for use as presentation material. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/b783e8b3-24e0-4893-896c-e4c1fe6995f1/LabEnvironment_2019_NE_watermarked.png 3D Modeling - Make it stand out A fun side project to fill some free time. Models were created in 3dsMax and may not be correctly sized as they were based on my personal memory and judgement based on the relationships between the objects. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587921718193-86I67PHHTXL4U7VPPDSX/toxoplasmosis_19-18_frame.jpg 3D Modeling - Make it stand out These assets were created from scratch in 3dsMax for an animation detailing the effects of toxoplasmosis. A short clip of the animation can be seen in my demo reel on the Animation page. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/af86a94b-6e03-4ff5-a4a0-cee0a7f671ae/HIV-viral-infection_NE_2018_watermarked.png 3D Modeling - Make it stand out These assets were created based on the PDB data for the HIV virus, along with other elements that were created in 3dsMax. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/ebcb8eb1-1c1a-4fcc-9409-a6043d2e8898/Chromosome_watermarked.png 3D Modeling - Make it stand out This chromatin fiber was created in 3dsMax for an animation. The model uses a relatively simple but custom base shape in combination with the VRayFur modifier to get the deeply textured effect. The end that is curling/condensing uses a helix spline, with the same VRayFur applied. A short clip of the animation can be seen in my demo reel on the Animation page. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/e0c00688-d716-4a74-a9b6-f1d1b139de72/ChromatinSignalingBALANCE_16x9_NE_2020_watermarked.png 3D Modeling - Make it stand out An opener for a presentation showing the balancing act of two protein complexes: POLYCOMB and COMPASS. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587861788978-PNY5IBV491SCL4QMC0G9/Ethen_N_StonyCoralReproduction.jpg 3D Modeling A life sciences poster displaying the life cycle of Stony Corals. All 3D assets were sculpted using ZBrush and exported to Keyshot for rendering. Render passes were composited in Photoshop, and labels added in Illustrator. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587847197386-494XQWGBEZ0QXCBHJWAH/Otoscope_nje150p.jpg 3D Modeling - Make it stand out A 3D model of an otoscope that was created for an animation as part of a group project. The purpose was to showcase showcase a medical device via an 'exploded view' but also to create a memorable and unexpected product advertisement of a doctor's common tool. My role for the project was modeler and animator. Without having access to an otoscope in person, the modeling was based heavily on measurements that were available and reference images. Modeling and animation was done in 3dsMax. A short clip of the animation can be seen in my demo reel on the Animation page. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/c8a19eba-7376-43d0-bb18-0760393be449/nature-genetics-cover-dec2020_ne_display.png 3D Modeling - Make it stand out “Epigenetic Clockwork.” The chromatin-regulatory network is depicted as a system of gears that represent nucleosomes, connected by DNA, with gauges representing functional outputs such as gene expression. This image was chosen as the cover for the Nature Genetics Volume 52 Issue 12 published in December 2020. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1551156081495-F3UIX9MHCG1C1EHV39XP/DefenseMechIRN_150dpi_NJE.jpg 3D Modeling - Make it stand out The main assets in this poster were created using Autodesk Mudbox. Supplemental environment assets and layout were done in 3dsMax with compositing in Photoshop and final layout and illustrations done in Illustrator. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587870432174-AKJT3AJZER73ZYRINFGX/BloodVessel_withRBCandWBC_20190401_150ppi.jpg 3D Modeling This image was designed for use by leukemia researchers for their presentations and displays the increased numbers of white blood cells as would be seen in leukemic patients. All assets, materials, lighting, and rendering were done in 3ds Max with final compositing in Photoshop. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/f0da2301-671d-4a99-a6b2-5720d473f886/BranchesOfExternalCarotidArtery_watermarked.jpg 3D Modeling This anatomical poster visualizes the branches of the external carotid artery. A preliminary 3D base was created from a 2D image stack using Materialise Mimics. The model then went through extensive clean-up. Lighting and materials were done in Keyshot, with final composition in Photoshop and InDesign. https://www.nicoleethen.com/branches-ext-carotid-artery daily 0.75 2020-04-26 https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1587860687065-0X3Y8H0CXPS2KYQA8L8M/branches-ext-carotid_150p.jpg Branches of External Carotid Artery https://www.nicoleethen.com/interactive-media daily 0.75 2025-04-05 https://www.nicoleethen.com/illustration daily 0.75 2025-04-05 https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/3cd14e00-8165-407e-9423-d117b3d87ae3/TRR-UTX_Figure_v3.1_2019_NE.png Illustration - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/2acfd08c-451e-4ec4-8629-7e1f993fa3e1/Cover_convertedto5by3.75_160p_NE_2020.png Illustration - Make it stand out A mockup of a cover image designed to accompany an article published in Molecular Cell. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/9d2b82fc-42d6-4529-8565-958a598b88f8/figure4_v5_watermarked.png Illustration - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/590f59db-e45f-4de0-9568-4f5e5f302c1b/nci-grant-fig_ne_2020.png Illustration - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/a723f218-3fec-46b4-b95f-b590d98ce68c/nature-genetics-cover-june2020_ne_display.png Illustration - Make it stand out “Equilibrium in the chromatin jungle.” This image depicts the potential epigenetic blockades to transcription. Lions (MLL2/COMPASS) keep zebras (PRC2) away, allowing the boat (RNA polymerase II) to travel down the river (DNA). When lions are not around (MLL2 knockout), zebras and crocodiles (DNA methyltransferases) block the boat. Without any animals, the boat is free to navigate. This illustration was chosen as the cover for the Nature Genetics Volume 52 Issue 6 published in June 2020. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/6da6b54a-d474-401b-a914-47903faa974e/figure5_v03_watermarked.png Illustration - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/f4555615-5a96-4cc6-91ed-10c9a786b86d/DNA-Packaging-NE_2020.png Illustration - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/f512b948-4ed9-4c86-b8b0-48d0d158d054/ShoulderAPViewVectorized2018-watermarked.png Illustration - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/1581660086848-0LE833XYRTGFMDMYILWZ/UICPTIllustration_150p.jpg Illustration - Make it stand out An editorial illustration to accompany an article about the decision-making process that a provider would have to make when determining if additional care or imaging is needed. https://images.squarespace-cdn.com/content/v1/5b7b8d93372b964632f696ae/99472190-688c-4d59-9564-7356c62a35ee/UrinarySystem_Unlabeled_Watermarked_2017.png Illustration - Make it stand out Whatever it is, the way you tell your story online can make all the difference.